How to improve gut microbiome and modify immune system response

How to improve gut microbiome and modify immune system response
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New research reveals live probiotics to be able to modify the immune system response and help us learn more about how to improve gut microbiome.

Published in the International Journal of Pharmaceutics, new research demonstrates that ‘good’ bacteria in the live probiotic SymproveTM can successfully reach and colonise the gut, where they have the ability to go on and change the existing gut flora – essentially uncovering a new research avenue in solving how to improve gut microbiome. They are also capable of modifying the immune system response.

How to improve gut microbiome

Researchers found that all bacteria in Symprove survived the acid within the stomach, which then reached and colonised the gut. The activity of the bacteria in this study were observed using a novel Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and used donor bacteria from healthy humans. This allows researchers to closely monitor bacteria through in-vitro simulation of the human gut, without the need for invasive procedures and measurements.

The bacteria in Symprove were tested to see if their colonisation would help feed the gut microbiome through the production of lactate. The microbiome has been identified as a disease modifier and an essential part of the immune system response.

Simon Gaisford, Professor of Pharmaceutics at University College London, UK, says, “We’ve been able to show that delivering viable and active bacteria to the gut impacts the healthy bacteria in our bodies in a way that we’ve not seen before. The diversity of the donor microbiotas clearly changed for the better and importantly the effect was sustained week-on-week.

“We saw that the addition of Symprove reduced inflammatory markers and raised butyrate levels. If we can make a healthy microbiome healthier, the potential to improve conditions of dysbiosis is incredibly exciting.”

The addition of the probiotics in Symprove to the microbiotas of healthy human donors changed the proportion of bacterial groups in the gut flora, which generated a significant increase in butyrate – a short chain fatty acid (SCFA) which is critical to health and wellbeing and enabled researchers to be one step closer in learning how to improve gut microbiome.

Modifying the immune system response

An increased abundance in beneficial bacteria such as firmicutes and actinobacteria were also observed after adding Symprove bacteria into the simulation containers. A lack of these bacteria in the gut is associated with several health conditions, including irritable bowel syndrome.

Barry Smith, Symprove Limited Founder and Chairman says: “Our research over the last 20 years has pushed to understand more about the microbiome and the essential role it plays in our overall health. This new research demonstrates the impact live and active probiotics can have on the body beyond the gut.

“It is incredibly exciting that leading academics are recognising the impact of feeding the microbiome. We all have a microbiome, and in many cases, we just need to help the bacteria that are already there.”

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