Neuron discovery could contribute to improved epilepsy treatment

Neuron discovery could contribute to improved epilepsy treatment
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Scientists have found that the way neurons are connected within the brain could provide a better indication of disease progression and lead to improved treatment outcomes for brain disorders such as epilepsy.

A group of scientists, led by Dr Marcus Kaiser from the School of Medicine at the University of Nottingham, looked at epilepsy patients undergoing surgery, finding that changes in the local network within brain regions can be a better predictor of disease progression, as well as whether surgery will be successful.

For the study, which has been published in Human Brain Mapping, the researchers at Nottingham, Newcastle, Qingdao, Shanghai, and Munich Universities, along with the company Biomax, evaluated the scans of 33 temporal lobe epilepsy patients and 36 control subjects.

Connectivity in the brain

The team found that looking at connectivity within regions of the brain showed superior results to the current approach, which only observes fibre tract connectivity between brain regions.

Dividing the surface of the brain into 50,000 network nodes of comparable size, each brain region could be studied as a local network with 100 to 500 nodes, which showed distinct changes compared to a control group not suffering from epileptic seizures.

The team demonstrated that fibres within and between brain regions are removed for patients, however, they found that connectivity within regions was a better predictor of whether surgical removal of brain tissue was successful in preventing future seizures.

Dr Kaiser, Professor of Neuroinformatics at the University of Nottingham, says: “When someone has an epileptic seizure, it ‘spreads’ through the brain. We found that local network changes occurred for regions along the main spreading pathways for seizures. Importantly, regions far away from the starting point of the seizure, for example in the opposite brain hemisphere, were involved.

“This indicates that the increased brain activity during seizures leads to changes in a wide range of brain regions. Furthermore, the longer patients suffered, the more regions showed local changes and the more severe were these changes.”

Project partners used the NeuroXM™ knowledge management platform to develop a knowledge model for high-resolution connectivity with more than 50,000 cortical nodes and several millions of connections and corresponding automated processing pipelines accessible through Biomax’s neuroimaging product NICARA™.

Project manager Dr Markus Butz-Ostendorf from Biomax commented: “Our software can be easily employed at hospitals and can also be combined with other kinds of data from genetics or from other imaging approaches such as PET, CT, or EEG.”

Professor Yanjiang Wang, who is one of the corresponding authors, and Ms Xue Chen, both from China University of Petroleum (East China), said: “Local connectivity was not only better in overall predictions but particularly successful in identifying patients where surgery did not lead to any improvement, identifying 95% of such cases compared to 90% when used connectivity between regions.”

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