Study shows that pharmaceutical CBD is best for reducing seizures

Study shows that pharmaceutical CBD is best for reducing seizures
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A new study has shown that ‘not all medical cannabis is the same’ by demonstrating how artisanal CBD is not as effective as pharmaceutical grade CBD products in treating epileptic seizures.

Children and teens with epilepsy who were treated with pharmaceutical CBD products had much better seizure control than those who were treated with artisanal CBD, according to a preliminary study to be presented at the American Academy of Neurology’s 72nd Annual Meeting in Toronto, Canada, April 25 to May 1, 2020.

CBD is a cannabis component that relieves stress and anxiety and has anti-seizure properties. It does not produce a “high” like another cannabis component called tetrahydrocannabinol (THC). Pharmaceutical CBD for epilepsy does not have THC.

CBD is FDA approved for use in two severe forms of childhood epilepsy, Dravet syndrome and Lennox-Gastaut syndrome, which do not respond well to other medications. Artisanal CBD is manufactured using varying techniques and contains variable amounts of CBD and THC.

Pharmaceutical CBD more effective for seizures

For the study, led by Nathan T. Cohen, M.D., of Children’s National Hospital in Washington D.C., and a member of the American Academy of Neurology, researchers reviewed the medical charts of 31 children and teens with an average age of 10 who were followed for an average age of one year.

All had some form of epilepsy including 32% with Lennox-Gastaut syndrome and 6% with Dravet syndrome. Of the group, 22 were taking pharmaceutical CBD and nine were taking artisanal CBD. Researchers recorded medication doses, levels of CBD in the blood, seizure history and reduction in seizures with medication and side effects.

Cohen said: “The use of medical cannabis to treat various medical conditions has grown in recent years. While not always legal, artisanal CBD has been available longer, so some people have been using it to treat epilepsy for years.

“They may want to reconsider because our research indicates that pharmaceutical CBD may indeed be more effective than artisanal CBD.”

Those in the study taking artisanal CBD had an average level of CBD in the blood of 31 nanograms per milliliter (ng/mL) compared to 124 ng/mL for those taking pharmaceutical CBD, and researchers found children and teens taking artisanal CBD had a 70% increase in seizures during the study. Those taking prescription CBD had a 39% reduction in seizures.

However, 11 participants reported side effects. All were taking pharmaceutical CBD. Side effects included sleepiness, low appetite, nausea and diarrhea. Six of those participants stopped taking pharmaceutical CBD due to side effects.

“The difference in seizure control is dramatic and is definitely of concern since many people continue to use artisanal CBD,” said Cohen. “However, a limitation of our study is that it was small. More research is needed to see if similar results are found in larger groups of people.”

Another limitation of the study was that it was a look back at medical records. It did not involve participants who were given either pharmaceutical or artisanal CBD and then followed over time.

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