Water-soluble delivery system improves CBD bioavailability and strength

Water-soluble delivery system improves CBD bioavailability and strength

A company has filed a patent for a technology that will help delivery of fat-soluble medications, including CBD.

Holista CollTech has filed its 100%-owned global patent for platform technology that will deliver many fat-soluble medications, including CBD, by creating a water-soluble delivery system.

Due to the way CBD is absorbed into the body, the new technology will make CBD formulations up to 40 times more potent, allowing patients to reduce their dosages significantly, as well as making CBD oil more palatable for the young and the elderly.

The bioavailability of CBD

Fat-soluble molecules have poor bioavailability as they don’t dissolve well and reach the bloodstream. As such, a higher dosage needs to be ingested. This is both wasteful and costly. This new platform technology will be of particular benefit to the cannabidiol (CBD) oil industry where the active material is scarce, costly and poorly water-soluble.

Project Leader and head of Holista’s Technical Advisory Panel, Dr Roscoe Moore Jr, said: “Working on developing this technology is exciting. Most medicine consumed orally is wasted due to its poor absorption by the body. This is especially true for CBD, which is also expensive.

“More important, the integrity of the final molecule is preserved exactly as it is found in nature and hence, there is no apparent need for any lengthy approvals process anywhere in the world. We only use materials certified as ‘Generally Regarded as Safe’ (GRAS) by the FDA”.

Dr Moore is the retired Assistant Surgeon General of the United States. He currently sits on several Company boards linked to CBD in the United States and Canada.

Oral consumption

CBD Oil has an earthy, musky and lingering bitter taste due to the high concentration of organic compounds that make it very unpalatable. This makes formulating CBD for oral consumption difficult. The taste masking technology linked to this patented formulation uses GRAS botanicals to allow wider applications in pharmaceutical and food with oral dosing.

“Holista drew from parallel work done on the turmeric molecule which is also very fat soluble” said Dr Swanand Malode, leader the teams in Europe and Asia that worked on this technology for more than five years.

CBD, a non-psychoactive cannabinoid found in cannabis, has had a surge in popularity over the past few years. Unlike Tetrahydrocannabinol (THC) the chemical compound that gives cannabis its psychoactive effects, CBD has been shown to help patients with Post Traumatic Stress Disorder (PTSD), anxiety, Multiple Sclerosis and epilepsy – without having the harmful effects.

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