ESHRE updates guidelines on endometriosis treatment

ESHRE updates guidelines on endometriosis treatment
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A new guideline on endometriosis treatment, management and diagnosis has been published by the European Society of Human Reproduction and Embryology (ESHRE).

The document outlines more than 100 recommendations on best practices on endometriosis treatment and care for women. The chronic condition causes severe pelvic pain and reduced fertility for millions worldwide.

The guideline provides the first update on endometriosis in seven years and addresses significant changes in clinical practice. Laparoscopy, previously a gold standard endometriosis treatment, is now only recommended in the guideline for specific cases such as patients who have symptoms, but their scan results come back negative. For pain management, hormone therapy is now recommended for patients’ post-surgery to suppress recurrence of symptoms.

Endometriosis treatment

Endometriosis is a condition where the tissue lining the womb starts to grow in other places, such as the ovaries and fallopian tubes. Endometriosis treatment includes pain killers, hormone medications, surgery and operations to remove the endometriosis tissue or the womb, however, there is no cure.

Endometriosis is underdiagnosed and can go undetected for years. In addition to informing medical practices, the 192-page document “highlights research gaps” in an area where “there are still a lot of unknowns”, said Dr Nathalie Vermeulen, a senior research specialist at ESHRE who helped draw up the guideline.

Christian Becker, who chaired the guideline development group, said endometriosis was very common, affecting approximately 190 million women worldwide but still “highly underrepresented”. “The symptoms such as pain and infertility are often devastating for patients and their families,” added Professor Becker, from the Endometriosis Care Centre, Nuffield Department of Women’s, and Reproductive Health at the University of Oxford. “The hope is that the new ESHRE endometriosis guideline will assist both patients and healthcare professionals in their decision making and understanding of the condition.”

Dr Vermeulen and Professor Becker have spent two years working with international medical specialists, epidemiological experts, and patient representatives to draw up the guideline document, which includes evaluation of surgical, medical, and non-pharmacological endometriosis treatment for pain management and infertility.

New recommendations

Based on the latest evidence, the recommendations primarily relate to the best endometriosis treatment and care for women of reproductive age but also address key gaps in clinical management. Adolescent endometriosis is covered for the first time, with recommendations on the diagnosis and appropriate treatments for symptom management in female adolescents and young adults. In addition, extended information is provided on menopause and guidance are given on pregnancy and fertility preservation in relation to endometriosis.

Endometriosis and cancer are other important topics covered in the guideline. The overall risk of cancer is not significantly higher in women with endometriosis, and the document strongly advises clinicians to inform women of this.

Patient representative Kathleen King – a member of the guideline development group – said the document would become “an essential part of the toolkit” for those living with endometriosis symptoms.

“I encourage all those with an interest in endometriosis to make full use of the guidelines,” added King, a medical scientist and former chair of the Endometriosis Association of Ireland. “Patients can feel confident in using the (lay version of the) guidelines to initiate discussions with their healthcare professionals, and their healthcare team have a guide based on current best practice and scientific information.”

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