Peripheral artery disease: Is cocoa the answer?

PAD. Peripheral Artery Disease acronym on sticky notes. Office desk background
© iStock/syahrir maulana

A new report by the American Heart Association reveals that the consumption of cocoa may improve walking performance for patients with peripheral artery disease

Peripheral artery disease or PAD is defined by a narrowing of the arteries that reduces blood flow from the heart to the legs. It affects over 8.5 million people over 40 years of age across America alone. The most common symptoms are pain, tightness, cramping, weakness or other discomforts in leg muscles in while walking.

The research published in the journal Circulation Research, reveals that the results from a small phase II clinical research trial whereby patients with the disease drank cocoa three times a day for six months.

In a small study of 44 peripheral artery disease patients over age 60, those who drank a beverage containing flavanol-rich cocoa three times a day for six months were able to walk up to 42.6 meters further in a six minute walking test, compared to those who drank the same number and type of beverages without cocoa.

Those who drank the flavanol-rich cocoa also had improved blood flow to their calves and some improved muscle function compared to the placebo group.

Damage in the powerhouse of the cell restricts walking performance

The lead study author Mary McDermott, M.D., professor of medicine and preventive medicine at the Feinberg School of Medicine at Northwestern University in Chicago said: “Few therapies are available for improving walking performance in people with PAD.

“In addition to reduced blood flow to the legs, people with peripheral artery disease have been shown to have damaged mitochondria in their calf muscles, perhaps caused by the reduced blood flow. Mitochondria are known as the powerhouse of the cell, converting food to energy.

“Previous research has shown that better mitochondrial health and activity are associated with better walking performance and improving the health of damaged mitochondria could lead to walking improvements.”

Epicatechins and flavanols

Researchers hypothesised that epicatechin, a major flavanol component of cocoa, may increase mitochondrial activity and muscle health in the calves of patients with lower extremity peripheral artery disease, potentially improving patient walking ability. Epicatechins and flavanols also have the potential to improve blood flow.

The cocoa used in the study is commonly available natural unsweetened cocoa powder, which is rich in the flavanol epicatechin, found in larger quantities in dark chocolate (>85% cacao) than in milk chocolate. Regular chocolate would not be expected to have the same effect.

The study participants were randomly assigned to drink milk or water mixed with the contents of a powder packet containing flavanol-rich cocoa (15 grams of cocoa and 75 mgs of epicatechin daily) or a placebo powder packet without cocoa or epicatechin three times daily over six months.

Walking performance was measured at the beginning of the study and at six months, with a 6-minute walking measured test twice – 2.5 hours after drinking the beverage and at 24 hours after drinking the beverage. Participants were also given a treadmill walking test and had the blood flow to their legs measured using magnetic resonance imaging (MRI). Participants who consented had a calf muscle biopsy to evaluate muscle health.

Cocoa consumption showed significant improvement

The research team discovered that the patients who consumed cocoa showed significant improvement – walking an average of almost 43 meters further in the six minute walking test compared to their baseline results during the test performed at 2.5 hours after the final study beverage.

Researchers also found increased mitochondrial activity, increased capillary density, and other improvements to muscle health in those who consumed the cocoa. Patients who drank the placebo beverage had a decline of 24.2 meters in their walking distance at 2.5 hours after the final study beverage compared to their baseline results.

This is consistent with other studies, in which people with PAD without treatment have declined in their six-minute walk distance over time.

Cocoa did not affect walking ability on a treadmill

Consumption of cocoa appeared to have no effect on treadmill walking performance. However, McDermott explained that the treadmill walking and the six mile walking test are distinct measures of walking endurance and do not respond identically to the same therapy. The improvement in six minute distance walking better reflects the type of walking required in daily life, and therefore, these results are a more relevant outcome for patients with PAD.

McDermott said: “While we expected the improvements in walking, we were particularly pleased to see that cocoa treatment was also associated with increased capillary density, limb perfusion, mitochondrial activity, and an additional measure of overall skeletal muscle health,

“If our results are confirmed in a larger trial, these findings suggest that cocoa, a relatively inexpensive, safe and accessible product, could potentially produce significant improvements in calf muscle health, blood flow, and walking performance for PAD patients.”

A prescription for chocolate?

Limits to this pilot study include a small sample size; an imbalance between the two study groups in the number of participants of each sex, race and in body mass index; and a lack of data for overall dietary consumption.

Naomi Hamburg, M.D., FAHA, Chair of the American Heart Association’s Peripheral Vascular Disease Council said: “Patients with PAD have difficulty walking that is as bad as people with advanced heart failure. Leg muscles don’t get enough blood supply in PAD leading to injury and in this study, cocoa appeared to be protecting the muscle and improving metabolism,”

“We know that exercise therapy helps people with PAD walk farther, and this early study suggests that cocoa may turn out to be a new way to treat people with PAD. We will need larger studies to confirm whether cocoa is an effective treatment for PAD, but maybe, someday, if the research supports it, we may be able to write a prescription for chocolate for our patients with PAD.”

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